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A substitution reaction is a type of chemical reaction that occurs when an atom or group of atoms in a molecule is replaced by another atom or group of atoms. This process can be used to create new molecules or to modify existing ones. In this study, we will examine the different types of substitution reactions, and look at some examples of each. We will also discuss the factors that influence a substitution reaction, and explore some of the applications of these reactions in chemistry and beyond!
Meaning of Substitution Reaction
Substitution reactions are important in organic chemistry because they can be used to make a wide variety of products. Nucleophilic substitution reactions occur when a nucleophile (a molecule that loves electrons) attacks an atom or group of atoms in a molecule and takes its place.
Conditions of Substitution Reaction
Certain conditions need to be satisfied for the substitution reaction for the occurrence which include:
– The presence of a leaving group: A leaving group is defined as a group that departs with electrons and leaves behind an electron-deficient (positively charged) atom or a molecule. Good leaving groups have weak bonds to their central atoms and are polarizable.
– Nucleophilic nature of the reactant: Nucleophilic reagents are those which have a lone pair of electrons and can donate these electrons to form a new covalent bond. Nucleophilic reagents are attracted to electron-deficient atoms.
– Electrophilic nature of the reactant: Electrophilic reagents are those which have a vacant orbital and can accept electrons to form a new covalent bond. Electrophilic reagents are attracted to electron-rich atoms.
Types Of Substitution Reaction:
There are two types of substitution reactions: Nucleophilic substitution reaction and Electrophilic substitution.
Nucleophilic Substitution Reaction: Nucleophiles are molecules that are attracted to electrons. Nucleophilic substitution reactions happen when a nucleophile attacks an electron-rich atom in a molecule and takes its place.
For example, the reaction between sodium chloride and silver nitrate to form sodium nitrate and silver chloride:
AgNO (aq) + NaCl(aq) → NaNO (aq) + AgCl(s)
In this reaction, the silver ion is the nucleophile and chlorine is the leaving group.
Electrophilic Substitution Reaction: Electrophiles are molecules that are attracted to electrons. Electrophilic substitution reactions happen when an electrophile attacks an electron-rich atom in a molecule and takes its place.
For example, the reaction between benzene and chlorine to form chlorobenzene:
Cl2 (aq) + C6H6 (s) → C6H5Cl(s) + HCl (g)
In this reaction, chlorine is the electrophile and benzene is the nucleophile.
Meaning Of Nucleophilic Substitution Reaction:
A nucleophilic substitution reaction is a type of chemical reaction in which one molecule replaces another molecule’s nucleophile. A nucleophile is an atom or molecule that is attracted to electrons. In other words, nucleophilic substitution reactions are a type of reaction in which an electron-rich molecule (the nucleophile) replaces another molecule’s electron-poor atom (the electrophile).
Types of Nucleophilic Substitution Reactions
Nucleophilic substitution reactions can be classified into two types: SN1 and SN2 reactions, which are of central importance in organic chemistry.
SN1 Reactions: Nucleophilic substitution with inversion of configuration. In an SNi reaction, the nucleophile attacks the carbon atom bearing the leaving group, causing the leaving group to be displaced. The carbon atom that was attacked by the nucleophile now has a partial negative charge.
SN2 Reactions: Nucleophilic substitution with retention of configuration. In an SNii reaction, the nucleophile attacks the carbon atom bearing the leaving group, causing the leaving group to be displaced. The carbon atom that was attacked by the nucleophile now has a partial positive charge.
An example of an SN1Â reaction is the hydrolysis of an ester to give carboxylic acid and alcohol.
An example of an SN2Â reaction is the alkylation of a primary amine to give a secondary amine.
Substitution Reaction Examples
Substitution reactions examples are given below.
Alkyl Bromide reactions of hydrolysis with water:
R-Br + H20 → R-OH + HBr
In the presence of a strong acid, such as HBr, the bromide ion (Br-) is a much better-leaving group than water.
S N Reactions:
The nucleophile (Nu) can be either inorganic, such as Cl- or I-, or organic, such as NH30H (the conjugate base of ammonia).
The electrophile, E+, can be either an alkyl halide, such as CH3Br, or an aryl halide, such as Ph-Br. An alkyl group is a carbon chain with hydrogens attached, while an aryl group is an aromatic ring with hydrogens attached.
Conclusion
From the study, it is evident that substitution reactions are crucial in various industrial and chemical processes. Substitution reactions are the reactions in which an atom or a group of atoms in a molecule is replaced by another atom or group. Nucleophilic substitution reactions play an important role in organic chemistry. The types of substitution reactions are classified based on the nature of the nucleophile and the electrophile. SN1, and SN2. Nucleophilic substitution reactions, in particular, are some of the most commonly used reactions in the industry. By understanding the different types of substitution reactions and their mechanisms, you can better control the outcome of these reactions.
