Gout MCQ

Gout is a very complicated kind of arthritis that can strike anyone at any point of time in their life. It’s marked by sudden, acute pain, swelling, redness, and tenderness in one or more joints, most commonly the big toe. Gout attacks might strike without any warning, it might wake you up in the middle of the night with the impression that your big toe is on fire. However, the weight of the bedsheet on the affected joint may appear uncomfortable as it is hot, swollen, and sensitive. The human body leads to the formation of uric acid as a result of the breakdown of purines, which can be found in certain foods and beverages. When one urinates, this natural byproduct passes through their kidneys and exits the body. The body is able to manufacture too much uric acid at times. Or the kidneys might be unable to deal with it. Uric acid crystals might get accumulated in the joints when the body’s uric acid levels are too high, a condition referred to as hyperuricemia. Gout is caused by sharp, needle-like crystals.  

Q1. Which among the following is not considered as a first – line option for the pharmacological treatment of gout ?

1. NSAİDS

2. Aspirin

3. Corticosteroids

4. Oral colchicine

Answer. The correct answer is option ‘2’ Aspirin. Aspirin is not used because it can change uric acid levels and potentially prolong and aggravate an acute attack, it is not recommended. When low-dose aspirin is added to a uric acid/gout therapy programme, it affects uric acid levels, increasing the likelihood of gout attacks and necessitating frequent uric acid monitoring. Nonsteroidal anti-inflammatory medications or corticosteroids are first-line treatments for acute gout, depending on comorbidities; colchicine is second-line treatment. Modifiable risk factors (e.g., high-purine diet, alcohol usage, obesity, diuretic medication) should be addressed after the first gout episode.

Q2.How long after the onset of an acute gout attack should pharmacologic therapy must be initiated ?

1. Within 1 hour

2. After 24 hour

3. Within 24 hour

4. After 48 hour

Answer. The correct answer is option ‘3’ within 24 hour. 

Q3. Can ice packs be considered as an effective adjuncts to the management of an acute gout attack ?

1. True

2. False

Answer. The correct answer is option ‘1’ true. By reducing inflammation and dulling pain signals, cold therapy can provide significant pain relief. If this treatment is effective for you, you can use the cold pack for 10 to 20 minutes at a time throughout the day.

Q4. Which among the following is suggested first – line therapy to consider ?

1. Febuxostat

2. Probenecid

3. Benzbromarone

4. Allopurinol

Answer. The correct answer is option ‘4’ allopurinol. Gout, high amounts of uric acid in the body produced by certain cancer medicines, and kidney stones are all treated with allopurinol. Allopurinol comes from the xanthine oxidase inhibitor class of drugs. It works by lowering uric acid production in the body. Gout attacks and kidney stones can both be caused by high uric acid levels. Allopurinol is used to avoid gout attacks rather than to treat them once they happen.

Q5. Accumulation of which of the following results in gout

1. Uric acid

2. WBC

3. Synovial fluid

4. Blood plasma

Answer. The correct answer is option ‘1’ uric acid. Gout is caused due to a higher accumulation of uric acid in the body, which is known as hyperuricemia. When the body breaks down purines, which can be found in both the body and the foods one eats, uric acid is produced.  

Q6. Which of the following ways can be used in the elimination of urea out of the body

1. Breathing

2. Metabolisation of liver

3. Urine

4. Sweat

Answer. The correct answer is option ‘3’ urine. The kidneys are basically responsible for removing urea from the body. The nephron is a tiny unit that filters urea from the blood.

Q7. People with gout should avoid consumption of which of the following

1. Dairy products

2. Alcohol

3. Both (a) and (b)

4. None of these

Answer. The correct answer is option ‘2’ alcohol. Alcohol reduces the body’s ability to eliminate uric acid, putting you at risk for hyperuricemia and a gout attack.  

Q8. Symptoms of gout might include 

1. Severe pain, warmth and swelling in the joint

2. Peeling, itching skin at the site of gout attack

3. Red or purple skin

4. All of the above

Answer. The correct answer is option ‘4’ all of the above. Acute gout attacks are distinguished by sudden onset of pain in the afflicted joint, as well as warmth, swelling, reddish staining, and tenderness. The most common attack location is the tiny joint at the base of the big toe. Ankles, knees, wrists, fingers, and elbows are among the other joints that might be impacted. The acute pain in some persons is so extreme that even touching the toe with a bed sheet produces terrible anguish. With or without treatment, these excruciating attacks normally pass in a matter of hours to days. An assault might linger for weeks in exceptional cases. Gout affects the majority of people at some point in their lives.

Q9. Among which of the following is the common site of gout attack?

1. Foot

2. Knee

3. Big toe

4. Ankle

Answer. The correct answer is option ‘3’ i.e. big toe. Gout is mainly associated with the big toe, but it can affect any joint.  The pain will likely get worse during the first four to twelve hours after it starts.

Q10. Which of the following increases a person’s risk for developing gout ?

1. High – salt diet

2. Asthma

3. Family history ( genetics )

4. All of the above

Answer. The correct answer is option ‘3’ family history (genetics). Gout is more common in persons who have a family history of the disease. The proportional contributions of genetic and environmental variables to gout aetiology are gender dimorphic.