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Surface Chemistry VII
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Mechanism of enzyme Catalysis

Shaillee Kaushal is teaching live on Unacademy Plus

Shaillee Kaushal
Faculty in Chemistry with a teaching experience of 14 years. Specialised in teaching for boards and competitions.

U
Unacademy user
thanks a lot of mam .....very nice explained....keep it up
  1. Mechanisms of enzyme catalysis: There are a number of cavities present on the surface of colloidal particles of enzymes These cavities are of characteristic shape and possess active groups such as NH2,-COOH SH,-0H etc. These are actually the active centers on the surface of enzyme particles The molecules of the reactant [substrate), which have complementary shape, fit into these cavities just like key fits into a lock on account of the presence of active groups, an activated complex is formed which the decomposes to yield the products E + S -E-S complex E + P


  2. Step 1: Binding of enzyme to substrate to form an activated complex: R 1 Step 2 Product formation in the activated complex ES-EP


  3. Step3:Decomposition of EP into products and enzyme again This mechanism accounts for high specificity of enzymatic reactions Rate = k2 [ES] 2E(i) Km+IS] km = Michaelis-Menten constant [S] = Concentration of substrate [E] Concentration of a enzyme


  4. Casel:When, [S] >km, then km can be neglected at-max = k2[E] Dividing equation i) by equation lii r max [S]+km When, Km = [S], r = 2 max Case ll: When ISl <<<km the reactions will be of second order Rate = k2[EIS] Km


  5. 1. Habers Process for manufacture 2. Ostwalds process for manufactures of nitric acid 3. Contact process for manufacture of sulphuric acid 4. Dacon process for manufacture of chlorine. 5. Polymerisation of ethene to Ti polythene Finely divided iron. Molbelenum as promoter Platinized asbestos v205 or platinized Asbestos. CuCl2 TiCl4 and AIR3 Ziegler Natta catalystl