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Details of glycolysis, steps, ATP production etc.

Dr Praveen Kumar Agrawal is teaching live on Unacademy Plus

Dr Praveen Kumar Agrawal
Ex - Faculty, Allen Kota, 22 Yrs Experience. Author - 17 books Known for best explanation Youtube : biology by pkagrawal

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sir aap acha karvate h aap bhot mehnat krte h aapke notes ki pdf leni h bhot psand h muje aapke notes👌👌👌👌👍👍👍
you explained very smoothly...😇😇
very good explanation
superb explanation sir
very helpful srji, clear cut explanation
COA-sh.....iska kya mtlb h ??
  1. Lesson 5 Glycolysis: First Step Dr. P. K. Agrawal M.Sc, Ph.D., CSIR NET (JRF), SRF, GATE, FIAZ Youtube Channel with over 1 million views 20 Years of Pre-medical teaching experience Ex- Faculty, Allen Career Institute, Kota Visit following link to follow my profile

  2. Glycolysis (EMP-Pathway) Common step for aerobic and anaerobic respiration. Glycolysis (Gr. Glycos sugar, lysis breakdown), is also called EMP pathway as it was discovered and first studied by Gustav Embden, Otto Meyerhoff and J. Parnas (all German biochemist). It is the basic and initial process in respiration, which is found in all organisms. (In anaerobes, it is the only respiratory process). RBCs also generate their energy by this process. . It involves the breakdown of one unit of glucose in to two units of pyruvic acid . It is an oxidative process but no oxygen is used and also there is no production of CO2. . Glycolysis takes place in the cytoplasm of the cell. From one glucose molecule (6 C compound), 2 molecules of pyruvic acid (3C compound) are formed. Overall equation for glycolysis can be written as: Glucose 2 NADP+2ADP 2iP2 (CGH1206) 2 Pyruvic acid 2ATP2 NADP+H (CH3-CO-COOH)

  3. Steps in glycolysis Glycolysis involves 3 main steps: 1. Phosphorylation of hexose sugar 2. Splitting of sugar into two 3C units 3. Formation of Pyruvic acid (pyruvate)

  4. Glucose (6C) ATP ADP Hexokinase Glucose-6-Phosphate Phospho-hexose isomerase Fructose-6-Phosphate ATP ADP Phospho-hexokinase Fructose-1,6-biphosphate Aldolase Dihydroxyacetone phosphate Glyceraldehyde 3-Phosphate Phospho-triose isomerase

  5. Dihydroxyacetone phosphate Glyceraldehyde 3-Phosphate Triose phosphate Triose phosphate NADP NADPH + H* NADP+ NADPH + H* iP iP 1,3-biphospho glyceric acid 1,3-biphosphoglyceric acid ADP ADP tra ATPtransphosphorylase ATP 3-Phospho glyceric acid 3-Phosphoglyceric acid 2-Phospho glyceric acid 2-Phospho glyceric acid H20 Enolase Enolase H20 Phosphoenol pyruvate ADP ATP Phosphoenol pyruvate ADP ATP Pyruvate kinase Pyruvate kinase Pyruvic acid (3C) Pyruvic acid (3C)

  6. ATP account of glycolysis ATP production of glycolysis is not very high, because it involves only a partial oxidation of glucose. However a total of 4 ATPs are directly generated (2 from glyceraldehyde 3 P and 2 from dihydroxyacetonephosphate). This ATP production is called direct phosphorylation. The reduced coenzyme INADH+ H, also contain a large amount of energy. But this energy is release only when these coenzyme are oxidised in ETS (described later). In ETS, each [NADH H], can give rise to 3 ATP. This type of ATP formation (in ETS) is called oxydative phosphorylation and it occurs in mitochondria. Net gain of ATP from glycolysis is summarised below ATP account of Glycolysis (a) Total number of ATP consumed in Glycolysis are 2 (b) Total number of ATP direct produced in Glycolysis 4 (c) Number of direct ATP gain-(b- a) 2 (d) Number of reduced coenzyme (NADHH) produced 2 (e) One [NADH+ H] can give 3 ATPs when transferred to the mitochondrial ETS. (f) Hence ATPs produced by NADH+H are 2 x3 6 (g) Net production of ATP from Glycolysis (c f 6+2 8

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