Dr Praveen Kumar Agrawal is teaching live on Unacademy Plus
Lesson 10 CORI CYCLE Dr. P. K. Agrawal M.Sc., Ph.D., CSIR NET (JRF), SRF, GATE, FIAZ Youtube Channel with over 1 million views 20 Years of Pre-medical teaching experience Ex Faculty, Allen Career Institute, Kota Visit following link to follow my profile https://unacademy.com/user/biologybypkagrawal-6909
Concept and Mechanism . In mammals, including humans, lactic acid is produced during oxygen stress, mainly in muscles due to anaerobic respiration. Excess of lactic acid which gets accumulated in the tissues develop severe pain and fatigue. So, when oxygen supply is restored, the lactic acid must be eliminated out fromm the concerned tissues. . So, when sufficient oxygen is available, the lactic acid undergoes aerobic oxidation to . However, some amount of the lactic acid produced by exercising skeletal muscles is . Within the liver cells, under, the enzyme lactic acid dehydrogenase (LDH) oxidizes lactic . This is the reverse of the step of the lactic acid pathway (fermentation) produce carbon dioxide and water. delivered by the blood to the liver. acid into pyruvic acid. . In the process NAD+ is reduced to NADH+ H+.
Concept and Mechanism . Unlike other organs, the liver is special in the sense that it contains the enzymes which can convert pyruvic acid molecules back into glucose 6-phosphate. This process is a just reverse of the glycolysis. Glucose 6-phosphate in liver cells can then be used as an intermediate for glycogen synthesis, or it can be converted to free glucose that is secreted into the blood So, during exercise, some of the lactic acid produced by skeletal muscles may be converted into the blood glucose by the liver. . This new glucose can serve as an energy source during exercise and can be used after exercise to help replenish the depleted muscle glycogern. . This two way traffic between skeletal muscles and the liver is called the Cori cycle.
Flow chart Skeletal muscles Liver Glycogen Glycogen Exercise Rest Blood Glucose 6-phosphate* GlucoseGlucose 6-phosphate Pyruvic acid Pyruvic acid Blood Lactic acid Lactic acid
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