Crohn’s Disease

Crohn’s disease is caused by abdominal dysfunction and metabolic damage due to digestion problems and malnutrition. Bleeding of the rectum and severe abdominal pain is the main inflammation caused due to Crohn’s disease. In this disease, bowel movement is essential to treat severe abdominal pain. Crohn’s disease is associated with anxiety and stress that also resulted in certain cardiovascular problems. Junk foods, high fat-containing food, and alcohol increase the chance of Crohn’s disease and bleeding of the rectum. Food high in Trans fat and fibre also increases the chance of other complications like ulcers, fistula and fissures due to bowel discharge problems.

Explanation of Crohn’s Disease:

Crohn’s disease is painful and is associated with the bleeding of the internal colon due to inflammation in the inner part of the rectum. The inflammation in the inner part also continues to the deep layer of the bowel causing bleeding. Weight loss due to malnutrition and blood in stool is the common characteristic of Crohn’s disease. Crohn’s disease increases the health effect due to Anemia resulting in Ischemic heart attack and degeneration of cells in the body. 

Auto Antigens that are responsible for the development of Crohn’s Disease:

Zymogene granule membrane or Glycoprotein 2 is the major antigen responsible for the development of Crohn’s disease. Rectal bleeding and irritation are the major symptoms of Crohn’s disease that are associated with Ulcerative Colitis. Autoimmune reaction attacks cells in the organs and creates difficulties for metabolic function. 

Causes:

1. An unhealthy diet and stress increase the chance of Crohn’s disease that resulting in the bleeding of the rectum.
2. Problems in the immunity system due to virus and bacterial infection trigger the disease of bowel inflammation.
3. Heredity is another cause that aggravates the chances of Crohn’s disease.
4. Consumption of toxic like alcohol or smoking cigarettes increases the inflammation in the bowel function.
5. Steroids and nonsteroidal anti-inflammatory medicine increase the risks of the disease among adults.

Symptoms of Crohn’s Disease:

1. Chronic Diarrhea, severe pain in the lower part of the colon, fatigue, bleeding in the rectum and inflammation due to constipation is the most common symptoms of Crohn’s disease. 
2. Bowel obstruction, Ulcer, and Fistula blood in stool are symptoms of the disease that needs to be treated very carefully. 
3. Anal fissure, osteoporosis, gall bladder, liver dysfunction and arthritis are the common symptoms of Crohn’s disease in the human body. 
4. Corticosteroid and lymphoma skin cancer is inhibited due to the inflammation in the inner parts of the abdomen and digestive tract of the body. 

Types of Crohn’s Disease:

There are mainly five types of Crohn’s disease that affect the digestive tract and internal part of the colon in the human body. 

1. Ileocolitis is the first type of Crohn’s disease that affects the internal ileum and large intestine in the body. 
2. Ileitis is another type of disease that affects the small intestine of the body. 
3. Gastroduodenal Crohn’s affects the whole stomach and beginning part of the small intestine or duodenum. 
4. Jejunoileitis is the 4th type of Crohn’s disease that refers to the inflammation in the upper region of the small intestine. 
5. Granulomatous Colitis is the 5th type of Crohn’s disease that affects a large portion of the Colon.

Treatment of Crohn’s Disease:

1. Stelara is the most recent common biological treatment method for Crohn’s disease. This drug helps in blocking the route of inflammation from the small intestine to the large intestine in the body. 
2. RHB104 is the new drug for medicating the patient with Crohn’s disease and removing pain in the digestive tract. 
3. Endoscopy and Colonoscopy are the medical diagnosis process to determine the rate of inflation in the colon or digestive tract. 
4. Fluoroscopic X-ray for imaging the inflammation in the small intestine is widely famous for the diagnosis of disease. 

CT scans and MRI scans are widely famous for the diagnosis of inflammation in the internal part of the colon. A biopsy is a major disease diagnosis process to determine the presence of cancer cells. 

Conclusion

The above study indicates that Crohn’s disease is mainly caused due to an unhealthy diet and problems with digestion. Risk factors increase due to the unhealthy diet and consumption of toxic compounds. Genetic factors also inhibit the chance of inflammation in the colon due to an increased risk of cell degeneration. Crohn’s disease causes joint pain and abdominal cramp due to acute inflammation in the inner part of the digestive tract and small intestine. Gastroduodenal Crohn’s disease includes vomiting, weight loss and malnutrition due to digestion problems. Ileitis is also associated with metabolic dysfunction that inhibits the growth of stones in the gallbladder.