Answer: All substances have the same amount of atoms or other particles in a mole. The mass of an element is related to the mole in the following way: A mole of carbon-12 atoms is made up of 6.02214076×1023atoms and weighs 12 grams. In comparison, one mole of oxygen has the same number of atoms as carbon-12 by definition, but it weighs 15.999 grammes. As a result, the mass of oxygen exceeds that of carbon. This logic can also be used to calculate molecule or formula weights.