Profile
Settings
Refer your friends
Sign out
The unique drug delivery mechanism used to deliver a medicine can greatly impact its efficacy. Some medications have an optimal concentration range within which they provide the most benefit, whereas quantities outside of this range might be harmful or provide no therapeutic value at all. On the other side, limited progress in the effectiveness of severe illness treatment has revealed an increasing need for a holistic perspective on therapeutic delivery to tissue sites. New approaches for managing pharmacokinetics, non-specific toxicity, pharmacodynamics, and medication efficacy emerged due to this. These innovative techniques are drug dry delivery systems (DDS), bioconjugate chemistry, molecular biology and combined polymer science.
The novel drug delivery system
The way medicine is administered can have a big impact on its effectiveness. Some medications have an optimal concentration range within which they provide the most benefit, whereas quantities outside of this range might be harmful or provide no therapeutic value at all. On the other hand, limited progress in the potency of severe illness treatment has revealed an increasing need for a multidisciplinary approach to therapeutic transport to tissue sites. Various drug delivery and drug targeting systems are now being developed to reduce drug degradation and loss, eliminate unwanted side effects, and increase drug bioavailability and the percentage of the medication accumulated in the necessary zone. Controlled and novel dry drug delivery, which was once simply a pipe dream or a potential, has become a reality. Pharmaceutical and other professionals have conducted a considerable and intensive study in this field of medication research during the previous decade-plus.
Soluble polymers, insoluble microparticles, synthetic and natural polymers, cells, cell ghosts, liposomes, and micelles are drug carriers. The carriers can be made to deteriorate progressively, react to stimuli (such as pH or temperature), and be aimed. The capacity to steer the drug-loaded system to the desired location is known as targeting.
Drug Delivery Carriers
Liquid crystal dispersions Micellar liquid, as well as nanoparticle dispersions comprising tiny particles with diameters of 10–400 nm, all show promise as drug delivery vehicles. . The purpose of these formulations is to create systems that have optimum drug loading and release qualities, as well as a long life cycle and low toxicity. The integrated drug contributes to the system’s microstructure and may potentially impact it through molecular interactions, especially if the drug has amphiphilic and/or mesogenic features.
Novel drug delivery system examples
These are the following novel dry drug delivery examples.
Transdermal Drug dry Delivery System refers to self-contained, discrete dose forms that deliver the medicine to the circulatory system at a controlled rate when placed on intact skin. The transdermal drug delivery system (TDDS) has become an important component of new drug delivery systems. Transdermal delivery is an intriguing alternative because it is both safe and reliable.
Mucoadhesive Drug dry Delivery Systems: Bioadhesion is the state in which interfacial forces hold 2 materials together for an extended time, at minimum, one of which is biological in origin. Mucoadhesion is the term used in pharmaceutics to describe the sticky connection to mucus or a mucous membrane.
Mucoadhesive polymers have been found to have a considerable impact on the residence time of sustained-release delivery systems on mucosal membranes in ophthalmic, nasal, vaginal, and buccal drug delivery systems. Furthermore, the creation of oral mucoadhesive delivery systems has always piqued my interest, as delivery systems capable of sticking to specific GI segments would provide several benefits.
Supramolecular Drug dry Delivery Systems: A supramolecular system comprises 2 or more molecular entities that are held together and organised by non-covalent intermolecular interactions. Supramolecular complexes containing macrocyclic molecules have piqued interest as models for studying natural supramolecular self-assembly and molecular recognition, as well as precursors for developing new nanomaterials for electronics, biological, and pharmacological applications.
Osmotically Controlled Drug dry Delivery Systems: Non-covalent molecular interactions hold two or more molecular entities together and organise them into a supramolecular system. Supramolecular complexes containing macrocyclic molecules have piqued interest as models for studying natural supramolecular self-assembly and molecular recognition and precursors for developing new nanomaterials for electronics, biological, and pharmacological applications.
Conclusion:
It can be concluded that the transformation of an existing therapeutic molecule from a traditional form to a novel delivery mechanism can increase patient compliance, safety and efficacy dramatically. Dry drug delivery examples are also discussed. An existing medication molecule can be given new life through a Drug Delivery System. A well-designed Novel Medication drug Delivery System can be a significant step forward in addressing issues linked to drug release at a specific place at a precise pace. Pharmaceutical companies are investing in the development of innovative drug delivery systems to give pharmaceuticals to patients more efficiently and with fewer side effects. This page discusses the fundamentals of Novel Drug Delivery Systems and the various varieties available.
