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Kerala PSC » Kerala PSC Study Materials » Immunology » Tumor antigens
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Tumor antigens

The tumour antigens are the proteins, glycoprotein, glycolipids, and carbohydrates expressed, otherwise known as life-saving antigens generated because of chemotherapy. These antigens are being used to research to develop formulae for efficient cancer vaccines.

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Immunology refers to two lines of defence of system in the human body such as initiative immune system (antigen-independent) where there is no specific mechanism to fight against an “invading antigens” and Adaptive immune system (antigen-dependent) which enables the host to emerge capable of responding with antigen exposure.  Tumour antigen is an antigenic material that is produced in tumour cells when chemotherapy leads to cells generating tumour markers.  

Tumour antigens 

Tumour antigens are a protein that is placed on the human body, and it produces the protein to make energy in the human body. This is to develop the antibody factors, which deliver the antinodes vaccines to the human body. However, it is a part of antigen-presenting cells in the human body. This is used to create a novel cancer vaccine, which is very important for the human body; hence, this is a protein type to recover the body pain and internal disease. There are various types of tumour antigens such as “aberrantly expressed or over-expressed” “cellular tumour antigens” produced by “cell-type-specific differentiation antigens”, “oncofetal antigens”, “monogenic viruses”, “altered cell surface glycolipids” and “glycoproteins”. So, these are the cells to protect the human body from an outsourced disease that is very harmful to the human body. However, this stopped to increase the dangerous disease and reduce the fact, which is developing.

Tumour-associated antigen

Tumour antigens are defined by a specific T cell of a response with a cancer testing antigen. Some significant lyses of cultivated tumour cells in “autologous cytotoxic T lymphocytes (CTL) in vitro” are observed in the “melanoma system”. The tumour-associated antigens (TAA) are successfully selected in hematopoietic malignancies. Even though the tumour is associated with a “malignant cell phenotype”, they are also intimate in normal cells; although in the expression of tumour-associated antigen (TAA) in malignant cells, there are special features that contribute to their immunogenicity. 

Carcinoembryonic antigen 

The substance is established on the origin of people that have colon cancer, it is the more types of cancer and infection, and who smoke tobacco. The carcinoembryonic antigen (CEA) quantity may help to keep the way of how well cancer treatment is active and if cancer has come on back. These are types of tumour markers and it is also known as “carcinoembryonic antigen (CEA)”. The purpose of “carcinoembryonic antigen” in a blood test is to diagnose and control defined types of cancers. The CEA tests are used especially in cancers in the larger entrails or rectum. 

The purpose for which CEA test is conducted is to estimate the presence or amount of Carcinoembryonic antigen in the patient’s test trial. They are CEA in types of tumour markers. The tumour markers are a structure that is found on their body in may be an indication of cancer and more healthy position. Immune response and mutation of tumour cells are sequentially assessed to determine the signal pathway that generates the antigen in the body. Cancer therapy with target cell analysis can be effective in identifying the relevant signal and induce therapeutic measures.

There are more types of testing is performed in several processes:

“Estimating cancer prognosis”-   It is ECP in a Prognosis of guesses of the anticipated route and outcomes with a disease. The doctors use CEA quantity along with other Elements in such as the phase and proportion of a person’s cancer to estimate the prognosis.

“Monitoring cancer Treatment”- The increase and decrease of CEA levels that are specified on a type in cancers that reflect on whether treatments are working effectively. 

“Detecting cancer recurrence”- The doctors repeatedly monitor CEA amount succeeding treatment in more cancers and as a way of difficulty in whether cancer is returned. ie. the patients on untimely “stage colon or rectal cancer” require to conduct CEA test every quarter to half yearly in the years following beginning treatment. 

Conclusion

According to the information available, tumour antigens help to create an antibody to prevent cancer disease. However, it has been necessary to know regarding cancer disease, which is a very harmful disease; the tumour antigen that is present in the normal cells and tumour cells. This helps to define the body cells from the out sources of the disease, hence it ready the human body cells to accept the cancer vaccine that is a very hard dose. This helps to develop cancer vaccines and immunotherapy. Hence, this therapy reduces the cancer effect on the human body. 

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