Human microbiome and immunity

To succeed in the mutual aim, the human microbiome and immunity are continuously shaping each other and describe the healthy individual’s unstable equilibrium. The microbiome is increasingly intricate in day immune situations such as autoimmunity, asthma, allergy, acquired or primary immune deficiencies. Development in the microbiome and immune system crosstalk understanding has ragged a close connection amid microbial groups and allergic disease development.  In this article, to discard the human microbiome database, establish the forensic microbiome database.

Human microbiome and immunity

Human microbiome

The human microbiome is defined as the collection of microorganisms that breathe in the human body or refer to the microbial genomes’ collection that subsidise the human metagenome or wider genetic representation. A genome that establishes the human microbiome, signifies the unusually several microorganism arrays which comprise archaea, bacteria, fungi, and nonliving viruses. The microbiome is most important for the development, nutrition, and immunity of humans.

The human microbiome definition is complicated and confused due to the words such as “microbiota” (the microbial taxa associated with people) and “microbiome” (the catalogue of such microbes and their genes) which are sometimes used interchangeably.

Immunity

Immunity is described as the ability of the human body to prevent the pathogen’s attack. The pathogen is the causing substance of foreign diseases such as viruses and bacteria and individuals are uncovered daily. Immunity describes their several types that are innate, passive, and active immunity.  

Human microbiome representative species

Some representative species is responsible for the human microbiome, these are:

• E. coli
• Staphylococcus aureus
• Helicobacter pylori
• Candida albicans
• Group A streptococcus
• Staphylococcus epidermidis
• Streptococcus pneumoniae
• Lactobacillus acidophilus etc.

Human microbiome database

The human microbiome is anticipated as the tool to inspect the diverse scientific questions, with the identification of various information of individuals. To discourse, the human microbiome database, establish the forensic microbiome database (FMD), that is the 16S rRNA data and related metadata collection produced from available data of the public. The fresh data was further regulated and managed with the use of a pipeline to make a standardised dataset for the analysis. Apart from the scientific feature, the FMD database also permits investigation and comparison of the sample of the microbiome from diverse geolocation and amid diverse sites of the body. The FMD’s goal is to offer the non-scientific and scientific communities tools and data to discover the microbiomes’ possibilities to respond to the scientific questions and assist as the model for such a type of future database.

Human gut microbiome database

Data repository for Gut Microbiota (GMrepo) is the Human gut microbiome database of reliably and curated annotated metagenomes of the human gut. The main purpose of the GMrepo is to augment the accessibility and reusability of the metagenomic data of the human gut and qualify cross-projects and comparisons of phenotype. Gut microbiota is significant in the normal physiology maintenance throughout the life of the host. With this database performed wide curation of metadata for every collected sample and comprises all conceivable connected metadata such as sex, age, country, BMI, and usage of recent antibodies. After that, it is reliably annotated the contents of the microbiome by conveying the sequencing delivers to units of taxonomy abundances related to the per-computed species with the state-of-the-art toolset.

Conclusion

This article focuses on the human microbiome representative species, human microbiome database, and human gut microbiome database. The human microbiome is anticipated as the tool to inspect the diverse scientific questions, with the identification of various information of individuals. To discourse, the human microbiome database, establish the forensic microbiome database (FMD), that is the 16S rRNA data and related metadata collection produced from available data of the public. Data repository for Gut Microbiota (GMrepo) is the Human gut microbiome database of reliably and curated annotated metagenomes of the human gut. The main purpose of the GMrepo is to augment the accessibility and reusability of the metagenomic data of the human gut and qualify cross-projects and comparisons of phenotype.