Leukotrienes are the family of the immune system mediators that produce the leukocytes, these essential fatty acids in the medication system. Leukotrienes are a type of module of a biologically active system that is formed by the macrophage, leukocyte cells and tissues. Leukotrienes respond to the cells for immunological as well as non-immunological stimuli in the human body. Leukotrienes are significantly in the family of standard “inflammatory mediators” that are produced in the leukocytes by the arachidonic acid and oxidations. Leukotrienes are used in order to repeat the signalling for conveying the information regarding the cell producing system and the neighbouring cells regulating systems. The production of liquid is usually accomplished by the production of “histamine” as well as prostaglandins. There are several ways that the Leukotrienes can cause diseases in this aspect. Doctors prescribe montelukast and zafirlukast.

Discussion

What are Leukotrienes?

As per the studies based on the Leukotrienes, it is highlighted that the objective is the component of eicosanoid inflammatory mediators developed through leukocytes and the oxidation method of arachidonic acid as well the fatty acid. The study based on the leukotriene highlights that the objective plates the role of antagonists as well as works as the medication in the human body. Leukotriene consists of zafirlukast, zileuton, and montelukast. However, the components of leukotrienes are essential to developing its structure as well as efficient to maintain its ability to control diseases such as asthma, allergies, and other chronic diseases related to breathing issues in the human body. Leukotriene is also effective in tightening the airway muscles and improving in providing mucosa and extra fluid.

How to decrease leukotrienes?

The biological studies based on several researchers emphasise that zafirlukast and montelukast are the most prescribed medication that doctors follow to develop the disease affected due to leukotrienes. The antibodies associated with these medicines are efficient to develop the lethal impact of the disease. It is also highlighted that leukotrienes are the component that consists of eicosatetraenoic fatty acid and enzymes therefore the components of this medicine are effective to construct a strong immune system that effectively increases the endurance ability of the human body.

What is the  structure of Leukotrienes?

The structure of Leukotrienes consists of the “G” protein family and a couple of receptors”. as well as constructed inflammatory chemicals that are effective when connected with the allergen or the allergy trigger. Leukotrienes belongs to the eicosanoid family and it is basically an inflammatory mediator whose structure is constituted through oxidation of arachidonic acid through enzymatic activity of arachidonate 5-Lipoxygenase.

What are the Functions of Leukotrienes ?

In order to attract white blood cells to the lining of Lungs Leukotrienes plays a significant role. Leukotrienes facilitate mucus production in the body. Airway muscles and its tightening solely depend upon Leukotrienes. Leukotrienes is a chemical that plays a decisive role in allergic rhinitis and asthma. Leukotriene has a severe impact on the human body as well as efficiently constructing several diseases in the human body. More specifically, most of the breathing issues emerge due to the Leukotrienes. However, it is necessary to develop proper resistance strength that is efficient to improve human health and prevent disease. As per the medical science and studies, it is noted that it creates several issues during the time of breathing as well as immerse health issues such as asthma, allergy, and several breathing-related problems in the human body.

What is the role of Leukotrienes in the human immune system?

Leukotrienes primarily affect “G protein-coupled receptors”. They might even act on sensors triggered by the peroxisome proliferator. Leukotrienes play a role in asthma as well as allergic conditions, as well as in the maintenance of inflammatory conditions. Asthma is usually treated with leukotriene receptor antagonists like montelukast as well as zafirlukast. “5-lipoxygenase” appears to play a function in cardiovascular as well as “neuropsychiatric diseases”, according to new studies. Leukotrienes have a crucial role in the proinflammatory reaction. Several, like LTB4, have such a chemotactic impact on moving macrophages, assisting in the delivery of the required cells to the area. Leukotrienes can cause “bronchospasm” and enhance capillary permeability.

Conclusion 

Leukotrienes decrease the production system of the body and have an impact negatively on allergic reactions and asthma.  From this perspective doctors prescribe montelukast and zafirlukast that help to reduce the little time and asthma which also provides relief from allergic activities. This medicine should be used to decrease Leukotrienes. Zileuton helps to provide relief from allergic rhinitis. Leukotrienes include such side effects with allergic reaction; it includes such flu-like symptoms and let the human being feel nervous as well as excitable. It also causes stomach aches, headaches, nausea, nasal congestion, vomiting, and many more.