Innate and Acquired Immunity

Introduction

When the body encounters foreign substances (antigens), the immune system strives to identify and eliminate the antigens.

Antibodies are produced when B cells are activated (also called immunoglobulins). These proteins bind to antigens in particular. Antibodies normally survive in our systems once they’re generated in case we have to battle the same infection again. That’s why a person who is in contact with an illness, such as chickenpox is unlikely to contract it again.

Immunizations (vaccines) work in a similar way to prevent some diseases. Immunization is a method of exposing the body to an antigen without making it sick. However, it allows the body to produce antibodies that defend the person from future germ attacks.

Antibodies can recognize and lock onto an antigen, but they can’t kill it independently. T cells are in charge of this. They destroy antigens that have been tagged by antibodies, as well as contaminated or altered cells. (Some T cells are even referred to be “killer cells.”) T cells also assist in signaling other cells (such as phagocytes) to perform their functions.

Antibodies can also

• Toxins (poisonous or harmful compounds) produced by various organisms are neutralized by activating a set of proteins termed complement, part of the immune system. Complement aids in the destruction of bacteria, viruses, and infected cells
• The immune system’s specialized cells and components protect the body from disease. Immunity is the term for this type of defense

Humans have three types of immunity — innate, adaptive, and passive:

• Innate (or natural) immunity is broad protection that everyone is born with. The epidermis, for example, works as a barrier to keep viruses out of the body. In addition, the immune system can tell when some invaders are alien and potentially harmful

• Acquired immunity (or adaptive immunity) is a type of immunity that develops over time. We acquire adaptive immunity when we are exposed to diseases or are inoculated against them with vaccinations

• Passive immunity is “stolen” from another source and only lasts briefly. Antibodies in a mother’s breast milk, for example, provide a baby with temporary protection from diseases the mother has been exposed to

Vaccines aid in the development of the immune system, which takes time. You can help keep your child as healthy as possible by getting all of your child’s prescribed immunizations on schedule.

Acquired immunity 

1. The acquired immune system comprises lymphocytes with antigen receptors that have been clonally selected (B cell receptors and T cell receptors).
2. Antigen receptors are genetically altered clonal receptors that bind to antigens presented on antigen-presenting cells by Major Histocompatibility Complex (MHC) molecules.
3. Memory T and B cells are produced during an adaptive immune response, allowing for a faster and more effective response to reinfection.
4. Immunologic memory is a characteristic of acquired immunity because it permits vertebrates to thrive in an environment that is constantly exposed to infections.
5. Cancer immunotherapy’s ultimate goal is to create immunologic memory against a tumor. However, just as it’s difficult to vaccinate HIV patients because the virus keeps evolving, it’s also difficult to build immunologic memory against a tumor that keeps acquiring mutations that allow immunological escape.

Innate immunity 

1. The innate immune system is the most evolutionarily conserved arm of the immune system, and it responds to signals from Pattern Recognition Receptors by generating fast, non-specific inflammatory responses (PRR).
2. PAMPs are pathogen-associated molecular patterns (PAMPs) that bind to PRRs and are found in bacteria, viruses, and other pathogens.
3. The innate immune response plays a critical role in infection management during the first seven days after infection.
4. To trigger the adaptive immune system, many cells in the innate immune system (such as dendritic cells, macrophages, mast cells, neutrophils, basophils, and eosinophils) generate cytokines or interact directly with other cells.
5. Other lymphocytes without antigen specificity, such as gamma-delta T cells and Natural Killer (NK) cells, are considered innate with some similarities to effector lymphocytes.

Innate and acquired immunity difference

Conclusion

The innate immune system provides nonspecific immunity from birth and does not require repeated pathogen contact. It can tell the difference between self and nonself. It possesses a wide range of infection resistance due to its nonspecificity. It is also hypothesized to function in adaptive immunity control by modulating co-stimulatory molecules and effector cytokines. Pattern recognition molecules/receptors, antimicrobial peptides, the complement system, inflammatory mediators, and cytokines released by immune cells are all examples of innate immunity. Pathogen-associated molecular patterns are necessary for microbe survival and pathogenicity, and pattern recognition molecules/receptors recognize them. Although innate immunity has lately gained prominence, more research is needed to understand its function better.