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CBSE Class 11 » CBSE Class 11 Study Materials » Biology » Central Dogma
CBSE

Central Dogma

The article discusses central dogma, transcription, translation, splicing, and related topics.

Table of Content
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According to the central dogma, DNA stores all of the knowledge needed to supply all of our proteins, and RNA may be a messenger that transports this information to the ribosomes. Within the cell, ribosomes work as factories, turning information from a code into a usable product. The process of translating DNA instructions into a functional product is named an organic phenomenon. Transcription and translation are the 2 processes of the organic phenomenon. During transcription, the DNA information in each cell is converted into little, portable RNA signals. Messages travel from the cell nucleus DNA to the ribosomes, where they’re read and translated into specific proteins. Within the case of retroviruses, like HIV, reverse transcription is the transfer of data from RNA to new DNA. 

All species on Earth have DNA as their genetic material. When DNA is passed down from parents to children, it can influence a number of the features of those who are young. Proteins, or more precisely, polypeptides, are the functional products of most known genes. Although many proteins are made of only 1 polypeptide, others contain numerous polypeptides. Protein-coding genes are people who code for polypeptides. 

Transcription: 

The process of transcribing a chunk of DNA into RNA is thought of as transcription. Messenger RNA could be a style of RNA that’s made from DNA segments that are translated into RNA molecules that may code for proteins (mRNA). One strand of the DNA that produces up a gene, called the non-coding strand, is a template for an enzyme called RNA polymerase to synthesise an identical (complementary) RNA strand. The best transcript is this strand of RNA. Nucleic acids, like DNA and RNA, use base pairs of nucleotides as a complementary language. An RNA polymerase reads a DNA sequence during transcription and creates a corresponding, antiparallel RNA strand termed a primary transcript. Messenger RNA (mRNA) is formed when a stretch of DNA is transcribed into an RNA molecule that encodes a protein; the mRNA then is a template for the protein’s creation through translation. RNA aids in the synthesis, regulation, and processing of proteins then plays a vital role in cell activity. RNA is often converted to DNA by some viruses (such as HIV, the AIDS virus). polymerase is the main enzyme involved in the synthesis of DNA from an RNA template.

Translation:

The translation is the process by which ribosomes within the cytoplasm or endoplasmic reticulum create proteins after DNA is converted to RNA within the nucleus. The organic phenomenon refers to the whole process. After folding into a vigorous protein, the polypeptide executes its duties within the cell. By forcing complementary tRNA anticodon sequences to bind to mRNA codons, the ribosome assists decoding. Because the mRNA goes through and is “read” by the ribosome, the tRNAs transport specific amino acids that are strung together into a polypeptide. Translation takes place within the cytoplasm of prokaryotes (bacteria and archaea). The translation process is split into three stages:

  •  Initiation: The ribosome forms a hoop around the mRNA target. The first tRNA is joined at the beginning codon. 
  • Elongation: The amino alkanoic acid carried by the ultimate tRNA validated by the little ribosomal subunit (accommodation) is transferred to the massive ribosomal subunit, which attaches it to at least one of the previously admitted tRNAs (transpeptidation). The ribosome then moves on to the following mRNA codon, generating an organic compound chain, and repeats the method (translocation). 
  • Termination: The ribosome releases the polypeptide when it reaches a stop codon. The ribosomal complex remains intact and continues to translate the subsequent mRNA.

Splicing:

In molecular biology, RNA splicing is the process by which a newly synthesised precursor messenger RNA (pre-mRNA) transcript is turned into a mature messenger RNA (mRNA). It works by linking exons and removing introns (RNA non-coding portions) (coding regions). Splicing of nuclear-encoded genes occurs either during or shortly after transcription in the nucleus. There are ribozymes called self-splicing introns that can catalyse their excision from their parent RNA molecule. Self-splicing introns are ribozymes that can catalyse their RNA molecule excision. Some RNA molecules have the potential to self-splice, and the discovery of this ability in the protozoan Tetrahymena thermophila was acknowledged with a Nobel Prize in 1989.

Splicing is placed in all kingdoms or realms of life, but the degree and forms of splicing vary greatly between the various divisions. Many protein-coding messenger RNAs and some non-coding RNAs are spliced in eukaryotes. Prokaryotes, on the other hand, splice non-coding RNAs only sometimes.

Conclusion:

A central dogma of biology is proof of how genetic information moves through a biological system. Within the most frequent or broad case, dogma provides a framework for understanding the transfer of sequence information between information-carrying biopolymers in living organisms. 

The central dogma explains how genetic information travels from DNA to RNA to protein. Because just 22 amino acids are encoded by 64 codons, the genetic code degenerates. Because it is the same in all creatures, the genetic code is universal. The process of replicating a DNA molecule is known as replication. The process of turning a specific sequence of DNA into RNA is known as transcription. The process through which a ribosome converts mRNA into a protein is known as translation.  Genes dictate the sequence of mRNA molecules, which in turn specify the sequence of proteins, according to this theory. Because the information stored in DNA is critical to cellular function, the cell copies it as RNA to protect it.

faq

Frequently Asked Questions

Get answers to the most common queries related to the CBSE Class 11 Examination Preparation.

What is the importance of central dogma?

Ans : DNA codes for RNA, which codes for proteins, according to molecular biol...Read full

What enzymes are involved in the central dogma of protein synthesis?

Ans: DNA ligase – utilised for DNA cloning; establishes a covalen...Read full

What is the exception of central dogma?

Ans: Many gene codes for RNA molecules are not translated into proteins and do not act as mRNAs. ...Read full

What is the eyepiece lens called?

 Ans: The eyepiece lens is known as an ocular lens.

Ans : DNA codes for RNA, which codes for proteins, according to molecular biology’s basic dogma. In some viruses, such as retroviruses, a mechanism known as reverse central dogma is used to convert the virus’s RNA genome into DNA.

Ans: DNA ligase – utilised for DNA cloning; establishes a covalent link between unbound single-stranded ends of DNA molecules during replication.

DNA polymerase – a protein that synthesises DNA from a DNA template and is employed in the radiolabeling of DNA probes, polymerase chain reactions, and cDNA cloning.

Ans: Many gene codes for RNA molecules are not translated into proteins and do not act as mRNAs.

RNA viruses, also known as retroviruses, reverse transcribe RNA into DNA, making them an exception to core dogma.

 

 Ans: The eyepiece lens is known as an ocular lens.

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