Lesson 14 of 17 • 68 upvotes • 8:36mins
The mechanism of action of both siRNAs and mIRNAs is mediated by Dicer and RISC complex. Dicer will cleave either pre-miRNAs or dsRNA to generate the final active molecules. As already pointed out when the complementarity between the acting RNA and the target is complete, we have a mRNA degradation (siRNA) induced by Ago2 that harbors endonuclease activity. In the case of miRNAs the complementarity is only partial with the target and we got translational repression mediated by RISC. Interestingly in plants miRNA are different from a animals, showing almost perfect matching with their targets and in this case they act as siRNAs.
17 lessons • 2h 22m
Course Overview (in Hindi)
5:28mins
Replication: Quick Revision (Part-1) (in Hindi)
8:47mins
Replication: Quick Revision (Part-2) (in Hindi)
8:27mins
Recombination: Quick Revision (in Hindi)
8:25mins
Mutation: Quick Revision (in Hindi)
8:41mins
DNA Repair:Quick Revision (in Hindi)
9:05mins
Transcription : Quick Revision (Part-1) (in Hindi)
9:03mins
Transcription: Quick Revision (Part-2) (in Hindi)
9:00mins
Processing of m-RNA: Quick Revision (Part-1) (in Hindi)
8:07mins
Processing of m-RNA : Quick Revision (Part-2) (in Hindi)
8:01mins
Processing of r- RNA and t-RNA: Quick Revision (in Hindi)
8:24mins
Prokaryotic Gene Regulation: Lac operan (in Hindi)
9:01mins
Prokaryotic Gene Regulation: Trp Operon (in Hindi)
8:19mins
Eukaryotic Gene Regulation (in Hindi)
8:36mins
Translation: Quick Revision (Part-1) (in Hindi)
8:10mins
Translation: Quick Revision (Part-2) (in Hindi)
8:17mins
Antibiotics and Post- Translational Modification (in Hindi)
8:12mins