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Cholinergic drugs
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Details of cholinergic receptors Muscarinic and Nicotinic

Akshaya Ranade is teaching live on Unacademy Plus

Akshaya Ranade
BAMS, MA Political Science with 4+ years of teaching experience; Appeared for UPSC mains 5 times and MPSC Mains twice.

U
Unacademy user
MP
sir, can u suggest me .. how to make notes of news paper ..its very time consuming for me
  1. Drugs acting on ANS


  2. Dual innervation of ANS Most organs receive both Sympathetic and Parasympathetic supply Exceptions: Only sympathetic: most BV, Sweat glands, hair follicles Only parasympathetic: Gastric and Pancreatic glands, ciliary muscles


  3. omati c ACh PGland 2. PM Sweat Gland arasympathetic: Ach Gland


  4. Adrenal Medulla Epinephrine TO Ach Circultion NarEpinaphie C2e1)


  5. Chol inerqic Receptors Muscarinic Nicotinic CM) muscles, GIT glands Blood vessels Muscarine CN ) Skeletal Muscles - heart, eye , Smooth & au autonomic ganglia permiability Nicotine X Atropine Atacunum etc


  6. Cholinergic receptors M1: ON SECRETORY GLANDS: salivation, acid secretion, lacrimation N: SKELETAL MUSCLE END PLATE: contraction N AUTONOMIC GANGLIA, ADRENAL MEDULLA: epinephrine secretiorn M2: HEART: HEART RATE M3: SMOOTH MUSCLES: contraction, bronchospasm, urination M3: PUPIL,CILIARY MUSCLES: miosis, aqueous humour flow


  7. Divided in 2 categories According to type of neuron 1. Cholinergic drugs 2. Adrenergic drugs Autonomic drugs are used for treatment of Angina, Heart failure, Hypertension, shock, Alzheimer's disease, Asthma, Benign Prostatic Hypertrophy


  8. Cholinergic drugs Also called parasympathomimetic drugs or cholinomimetic drugs Stimulate the action of parasympathetic system as does ACh Types Direct acting Indirect acting


  9. Direct acting cholinergic agonists sLUDD-MB Bind directly to receptors, lipid insoluble Effects are peripheral as they do not enter CNS readily Acetylcholine, Methacholine, Carbachol, Muscarine, Pilocarpine, Common effects: 1. Cardiovascular: bradycardia, vasodilation 2. GIT: increase gastric secretion, salivation, git motility, urinary frequency 3. Pupil constriction, sweating 4. Respiratory: bronchoconstriction


  10. BETHANCHOL Not hydrolysed by acetylcholinesterases Stimulates M receptors, detrusor muscles of bladder Used in: urine retention, paralytic ileus, post-op atony of git/bladder, GERD Dose 10-50 mg PO or 10-20 mg SC * TDS/QID Contraindicated in GIT obstruction/bladder obstruction, bradycardia, peptic ulcers, asthma, COPD