Direct interaction between cells and between cells and the extracellular matrix are critical to the development and Function of multicellular organisms. Some cell – cell interactions are transient and some are stable , both play an important role in interaction. Given below are some statements , identify the combination of incorrect statements :-

A) Binding of ICAMs to integrin is an example of homophilic interactions.

B) Selectins mediate transient interactions between leukocytes and endothelial cells or blood platelets.

C) Tight junctions separate the apical and basolateral domains of the plasma membrane by allowing the free diffusion of lipids and membrane proteins between them.

D) Gap junctions also allow the passage of some intracellular signalling molecules such as Camp , and Ca2+ , between adjacent cells .