A 45 year-old homeless female is found unconscious in the street. Her urine drug screen is positive for heroin. She is febrile and when she awakes she notes that she has been having problems with chest pain, shortness of breath and a cough. Physical exam reveals a high-pitched holosystolic murmur heard best at the apex, dark red lesions in the nailbeds and diffuse petechiae. Histology of her damaged heart valve would most likely show which of the following?
Predominantly eosinophilic and monocytic infiltrate
Coagulative necrosis with nuclear pyknosis
Non-necrotizing granulomas and giant cells
Bacterial invasion with a predominantly neutrophilic response
Clumps of fibrin on the valvular leaflet
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